Probably all people, as soon as pain appears, willfully resort to known medications that relieve pain, instead of studying the instructions or consulting with a specialist. In order for as many people as possible to avoid harm from this approach, in the article we will describe one of those pharmacological products that are used most often, talk about the dosage and method of taking it, as well as contraindications.
This remedy is Nimesil, a drug belonging to the NSAID group. This abbreviation stands for “non-steroidal anti-inflammatory drug.” The release form of this medicine is granulated powder for suspension. Packaged in sachets of two grams. You can buy individually or in boxes of thirty bags, which also come with instructions.
"Nimesil": reviews for osteochondrosis
The advantages of Nimesil are obvious. This drug is a very popular analgesic and anti-inflammatory agent. It is usually prescribed to those who have back or joint pain, to those who have suffered injuries, dislocations, and sprains. In addition to pain relief and fighting inflammation, Nimesil also reduces fever. This drug is available in powder form, which accelerates its absorption into the blood. Thanks to this, it is faster than the well-known aspirin in terms of speed of action. The main advantage of Nimesil is that long-term use of this product does not impair its tolerance by the body.
Yes, the duration of use of this drug does not in any way affect how well it is tolerated. But it is still important to consider contraindications.
What is the drug made from and how does it work?
"Nimesil" contains the main and additional components. Here's what it contains:
- nimesulide. This is the main component. It is a COX (cyclooxygenase) inhibitor. Nimesulide stops the release of inflammatory agents, thereby eliminating pain;
- maltodextrin;
- ketomacrogol;
- anhydrous citric acid;
- sucrose;
- orange juice, thanks to which the medicine has a pleasant orange smell.
The main active ingredient of Nimesil is nimesulide.
All these ingredients, except nimesulide, are auxiliary in this medicine. Thanks to them, it quickly has an anti-inflammatory and analgesic effect, and reduces temperature.
Active ingredients of Nimesil
This medication is a light yellow powder with a slight orange odor. "Nimesulide", which is its main component, is supplemented with additives for taste and smell:
- flavoring;
- sucrose;
- lemon acid.
In addition, the preparation also contains cetomacrogol 1000. This substance is an auxiliary ingredient not only for medicines. It is used by perfume companies and food manufacturers. Cetomacrogol is a solubilizer. Simply put, it allows components to dissolve that otherwise cannot do so. This substance can also be used as an emulsifier. In short, it can be used to connect the incompatible.
What kind of substance is nimesulide and how does its action manifest itself? This component is a non-steroidal anti-inflammatory drug that belongs to the sulfonanilide group. It is not an antibiotic, although it is a derivative of one of them - a sulfonamide. Nimesulide blocks enzymes that are important for the production of prostaglandins - physiologically active substances, due to which the affected areas begin to swell, ache, and become inflamed. Although these substances were so named because they were first isolated from seminal fluid, they are produced throughout the body. Prostaglandins trigger a full-fledged chain reaction. Their effects affect the cardiovascular system as well as the immune system.
The active substance inhibits the activity of enzymes that contribute to pain
The action of most NSAIDs is aimed at stopping or at least slowing down the production of prostaglandins. These drugs block the enzymes that are needed to make these substances from essential fatty amino acids. The other two drugs, aspirin and ibuprofen, have approximately the same effect on the human body. In contrast, Nimesil does not interfere with the functioning of gastrointestinal enzymes, despite the fact that it blocks similar ones that are involved in the production of prostaglandins. But even this gentle action does not save you from the harmful effects of the drug on the mucous membrane of the digestive system, liver, and so on, if they are affected by diseases.
Nimesil
Use during pregnancy and breastfeeding
Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, the drug is contraindicated during pregnancy and breastfeeding.
Use for liver dysfunction
The drug is contraindicated in liver failure or any active liver disease.
Use for renal impairment
In patients with renal failure, Nimesil should be used with caution, as renal function may deteriorate.
If the condition worsens, treatment with Nimesil should be stopped. The drug is contraindicated in severe renal failure (creatinine clearance <30 ml/min). In patients with mild to moderate forms of renal failure (creatinine clearance 30-80 ml/min), there is no need for dose adjustment.
Use in children
The drug is contraindicated in children under 12 years of age.
Adolescents (ages 12 to 18 years): Based on the pharmacokinetic profile and pharmacodynamic characteristics of nimesulide, no dose adjustment is necessary in adolescents.
special instructions
Undesirable side effects can be minimized by using the minimum effective dose of the drug for the shortest possible short course.
Nimesil should be used with caution in patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.
The risk of gastrointestinal bleeding, ulceration or perforation of an ulcer increases with increasing dose of NSAIDs in patients with a history of ulcers, especially those complicated by bleeding or perforation, and in elderly patients, so treatment should be started with the lowest possible dose. Patients receiving drugs that reduce blood clotting or inhibit platelet aggregation also have an increased risk of gastrointestinal bleeding. If gastrointestinal bleeding or ulcers occur in patients taking Nimesil, treatment with the drug should be discontinued.
Since Nimesil is partially excreted by the kidneys, its dosage for patients with impaired renal function should be reduced, depending on the level of urination.
There is evidence of rare cases of liver reactions. If signs of liver damage appear (itching, yellowing of the skin, nausea, vomiting, abdominal pain, dark urine, increased activity of liver transaminases), you should stop taking the drug and consult your doctor.
Despite the rarity of visual impairment in patients taking nimesulide concomitantly with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist.
The drug can cause fluid retention in tissues, so patients with high blood pressure and cardiac problems should use Nimesil with extreme caution.
In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be stopped.
Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There is insufficient data to exclude the risk of such events when using nimesulide.
The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. Nimesil is not recommended for use in patients with rare hereditary diseases of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency.
If signs of a “cold” or acute respiratory viral infection occur during treatment with Nimesil, the drug should be discontinued.
Nimesil should not be used simultaneously with other NSAIDs.
Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases.
Elderly patients are especially susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforation, deterioration of renal, liver and cardiac function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary.
Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can negatively affect female fertility and is not recommended for women planning pregnancy. When planning a pregnancy, consultation with your doctor is necessary.
There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first signs of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, Nimesil should be discontinued.
The effect of the drug on the ability to drive vehicles and operate machinery.
The effect of the drug Nimesil on the ability to drive vehicles and operate machinery has not been studied, therefore, during treatment with the drug Nimesil, caution should be exercised when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
When is the drug prescribed?
Doctors prescribe this medication when the patient feels acute pain. The indications are as follows:
- pain caused by injuries;
- tendinitis;
- pain from menstruation (in women);
- tooth pain;
- osteoarthrosis, osteochondrosis;
- myalgia;
- bursitis;
- arthritis;
- rheumatoid arthritis;
- arthralgia.
The drug is prescribed for pain caused by both diseases of the spine and pathologies of internal organs
For quite a long time, this medicine was prescribed for common colds and other pathologies that increase body temperature. However, this is now a dubious indication: Nimesil is now prescribed only if none of the other NSAIDs helps. It is especially often used for back pain caused by pathologies of the locomotor system, in particular osteochondrosis.
Combination of Nimesil with other medications
If you are planning to combine Nimesil with any other medications, you should first consult a specialist. If you use this medicine together with some other drugs, firstly, it will increase the likelihood of bleeding, and secondly, their effect will be weakened.
For example, taking Nimesil along with antiplatelet medications is a bad idea, since this can greatly increase the likelihood of bleeding in the gastrointestinal tract.
If you take this medicine along with anticoagulants, their effect will be increased, but the likelihood of bleeding will also increase. So for those with impaired coagulation, NSAIDs are very rarely prescribed. If you need to take Nimesil, you should monitor blood clotting as carefully as possible.
When combining Nimesil with lithium preparations, it is also necessary to continuously monitor physical indicators. Taking a drug containing nimesulide makes the elimination of lithium slower, thereby increasing the concentration of this metal in the blood and its toxicity.
If you use Nimesil with methotrexate drugs, the negative effect of the latter also increases.
"Nimesil" is not allowed to be taken simultaneously with every drug
Using nimesulide preparations together with diuretics or furosemide is also not a very good idea: the effect of these two types of drugs will be weakened.
Instructions for use NIMESIL
Undesirable side effects can be minimized by using the lowest effective dose for the shortest duration necessary to control disease symptoms, as well as gastrointestinal and cardiovascular risks, below).
If there is no improvement in symptoms, drug therapy should be discontinued.
Rare cases of serious liver reactions, including very rare cases of death, have been reported associated with the use of nimesulide-containing medicinal products. Patients who experience symptoms similar to those of liver damage during treatment with Nimesil® (for example, anorexia, nausea, vomiting, abdominal pain, fatigue, dark urine) or patients whose laboratory tests of liver function deviate from normal values, should discontinue treatment with the drug. Repeated administration of nimesulide is contraindicated in such patients. Liver damage, most reversible, has been reported after short-term exposure to the drug.
During treatment with Nimesil®, the patient should refrain from taking other analgesics. The concomitant use of Nimesil® and other NSAIDs, including selective cyclooxygenase-2 inhibitors, should be avoided.
Patients receiving nimesulide who develop flu-like or cold-like symptoms should discontinue treatment with the drug.
Elderly patients:
Elderly patients have an increased incidence of adverse reactions to non-steroidal anti-inflammatory drugs, especially the incidence of gastrointestinal bleeding and perforation, which can be fatal to the patient.
Gastrointestinal bleeding, ulcer and ulcer perforation:
Gastrointestinal bleeding, ulceration and ulcer perforation may be life-threatening if the patient's medical history shows similar problems occurring when taking any non-steroidal anti-inflammatory drugs during treatment (regardless of the elapsed time), with or without the presence of dangerous symptoms, or the presence of history of serious gastrointestinal disorders.
The risk of gastrointestinal bleeding, ulceration, or perforation of an ulcer increases with increasing doses of nonsteroidal anti-inflammatory drugs, in patients with a history of ulcers, especially those complicated by hemorrhage or perforation, and in elderly patients. For these patients, treatment should be started with the lowest possible dose. For these patients, as well as patients taking concomitant low-dose aspirin or other drugs that increase the risk of gastrointestinal disease, combination therapy with protective agents (eg, misoprostol or proton pump inhibitors) should be considered.
Patients with gastrointestinal toxicity, especially the elderly, should report any unusual gastrointestinal symptoms (especially gastrointestinal bleeding). This is especially important in the initial stages of treatment. Patients taking concomitant medications that may increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors, or antiplatelet agents such as aspirin, should be advised to use the drug with caution.
If gastrointestinal bleeding or ulcers occur in patients receiving Nimesil®, treatment with the drug should be discontinued.
NSAIDs should be prescribed with caution to patients with a history of gastrointestinal diseases (ulcerative colitis, Crohn's disease), since exacerbation of these diseases is possible.
Disorders of the cardiovascular and cerebrovascular systems:
Patients with arterial hypertension and/or a history of mild/moderate acute heart failure, as well as patients with fluid retention and edema as a reaction to the use of NSAID therapy, require appropriate monitoring of their condition and consultation with a physician.
Clinical studies and epidemiological data suggest that some nonsteroidal anti-inflammatory drugs, especially at high doses and when used for long periods of time, may lead to a small risk of arterial thrombotic events (eg, myocardial infarction or stroke). There is insufficient data to exclude the risk of such events when using nimesulide.
In patients with uncontrolled hypertension, acute heart failure, established coronary artery disease, peripheral arterial disease and/or cerebrovascular disease, nimesulide should be prescribed after careful evaluation. An equally careful consideration of the condition should be performed before initiating long-term treatment in patients with risk factors for cardiovascular disease (eg, hypertension, hyperlipidemia, diabetes mellitus, smoking).
In patients with renal or heart failure, Nimesil® should be used with caution, as the drug may worsen renal function. If the condition worsens, treatment should be discontinued.
Elderly patients are particularly susceptible to adverse reactions to NSAIDs, including gastrointestinal bleeding and perforation, and deterioration of renal, hepatic, and cardiac function. Therefore, appropriate clinical monitoring is advisable.
Since nimesulide can affect platelet function, it should be prescribed with caution to patients with bleeding diathesis. However, Nimesil® does not replace acetylsalicylic acid in the prevention of cardiovascular diseases.
There are very rare reports of serious skin reactions to non-steroidal anti-inflammatory drugs, some of which can be fatal. Including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Patients are at very high risk of such reactions if, with a previously prescribed course of treatment, the onset of the reaction in most cases occurred during the first month of treatment. Nimesil® should be discontinued at the first signs of a skin rash, damage to the mucous membranes and other signs of an allergic reaction.
Nimesil® contains sucrose. This drug should not be prescribed to patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase deficiency.
Impact on the ability to drive vehicles and operate machinery
Studies on the effects of nimesulide-containing drugs on the ability to drive vehicles and operate machines and mechanisms have not been conducted. Despite this, patients experiencing headache, dizziness or drowsiness after taking Nimesil® should not drive a vehicle, machinery or machinery.
When should you not take Nimesil, what are its side effects?
This medication should not be used to treat children. Even in the most extreme case, the patient's age should in no case be less than twelve years.
Also, this drug should not be taken in case of severe liver and kidney diseases, ulcerations and erosions, or diabetes mellitus.
It cannot be used for the following pathologies if they arose as a result of the use of non-steroidal anti-inflammatory drugs:
- bronchospasms;
- hives;
- allergic rhinitis.
You should not take Nimesil if hepatotoxic reactions to non-steroidal anti-inflammatory drugs are detected.
It is also not used in combination with the following:
- paracetamol;
- analgesics;
- any non-steroidal anti-inflammatory drugs, except, in fact, Nimesil itself.
Here is a list of pathologies and their stages for which this drug is unsuitable:
- exacerbation of intestinal inflammation;
- rehabilitation period after coronary artery bypass surgery;
- fever coupled with infections;
- complete/partial combination of asthma with recurrent polyposis of the nasal/paranasal sinuses;
- exacerbation of gastrointestinal ulcers;
- cerebrovascular bleeding;
- tendency to bleeding, hemorrhage;
- a serious form of cardiovascular failure;
- liver poisoning;
- alcoholism;
- drug addict.
Before starting to take the drug, you should consult your doctor to avoid any complications.
Finally, Nimesil should not be used by those who are highly sensitive to any of its components.
Contraindications and side effects
Nimesil should not be prescribed for:
- individual intolerance in patients to nimesulide and excipients of the drug;
- stomach and duodenal ulcers;
- inflammation of the digestive system and bleeding;
- the occurrence of bronchospasm and runny nose while taking aspirin or other NSAIDs;
- coronary artery bypass surgery that the patient underwent;
- high blood pressure;
- pregnancy and breastfeeding;
- diabetes mellitus, which belongs to type II.
Taking the drug is prohibited for adolescents under 12 years of age and is not recommended for patients with impaired renal function, since the removal of the drug from the body can lead to a deterioration in their function.
The medicine should not be used for more than two weeks, because the drug is hepatotoxic and leads to a weakening of the protective function of the liver.
When prescribing Nimesil, side effects occur rarely and include:
- increased blood pressure and increased heart rate
- allergies - sweating, itching, skin rashes, dermatitis and urticaria
- decreased levels of hemoglobin or platelets in the blood
- malfunction of the nervous system - sleep and vision disturbances, anxiety and weakness
- disorders of the digestive system - nausea, vomiting, diarrhea, bloating and exacerbation of gastritis
- depression of respiratory functions - shortness of breath, increased frequency of attacks of bronchial asthma.
Preparation of a suspension from powder
Each Nimesil sachet contains one dose of the drug. The suspension should be prepared as follows:
- prepare half a glass of boiled water at ambient temperature;
- pour a dose of the drug from the sachet there;
- mix as thoroughly as possible.
It is unacceptable that the water temperature is too high or low. And every particle must be dissolved.
If everything is done correctly, the resulting suspension can be used.
How to use Nimesila suspension?
The prepared drug is drunk a couple of times a day, one sachet. Each of them contains one hundred mg of nimesulide. The dose of the medicine lasts for a quarter of a day while it fights inflammation and swelling. It is recommended to take this medication after meals. It is unacceptable to store the finished suspension. It must be drunk immediately after preparation.
This medication should never be prescribed to children and adolescents under twelve years of age. Greater care is also required when prescribing it to older people. Due to the negative effect of the drug base on the liver and kidneys, patients in whom these organs are unhealthy should first consult a specialist to adjust the dose.
Popular questions about Nimesil:
Nimesil how to take the drug?
Adults and adolescents over 12 years of age are prescribed 1 sachet orally twice a day after meals.
How to dilute Nimesil?
The powder from the bag is dissolved in half a glass of warm water, mixed and the finished solution is drunk.
How to take Nimesil for toothache?
An adult and a teenager are prescribed to drink 1 sachet, which is dissolved in half a glass of water and taken twice a day. The time interval between doses is 12 hours. The single dose is not increased.
How often can you take nimesil?
Doctors prescribe the drug in a short course to eliminate pain and symptoms of inflammation. The medicine should not be taken for more than two weeks.
The nuances of using this medicine
If you read the instructions for Nimesil, you can find out how to minimize the likelihood of side effects from the drug. Here you just need to follow some rules of application:
- By taking the product after meals, you can reduce the likelihood of getting gastrointestinal pathologies;
- until the course ends, you cannot drink a drop of alcohol;
- It is best to use just enough of the drug to help, but no more. For example, if you have a cold, you can take just a couple of sachets twice a day instead of the three recommended for the flu and its symptoms;
- when the symptoms are reduced, and inflammation, temperature and pain are relieved, Nimesil should be stopped;
- a possible increase in body temperature during the Nimesil course is a sign that the active component of the medicine is not suitable for the patient, and the use of this drug should be immediately interrupted.
Video - How to properly dilute Nimesil?
How to take Nimesil?
The drug is prescribed to adults and adolescents from 12 years of age, 1 sachet twice a day after meals.
The granules are dissolved in half a glass of warm water, mixed and drunk immediately, since the medicine is prepared before use.
Nimesil for toothache reduces the patient's suffering within 20 minutes, reduces temperature and reduces swelling in tissues during inflammatory diseases in the oral cavity. The drug is used to relieve the symptoms of the disease, so the patient needs to see a dentist.
Nimesil for headaches is used to relieve attacks that are caused by migraines and occur due to changes in weather conditions, fatigue or stressful situations. A single dose is enough for the patient; improvement occurs within 40 minutes and lasts 12 hours.
Nimesil in gynecology is prescribed for premenstrual syndrome, inflammation of the female organs, and endometriosis. The dosage form in powder form is absorbed and acts faster than tablets. A decrease in inflammation symptoms occurs on the second day of treatment.
Nimesil during menstruation is used on the first day of the cycle or two days before the start of menstruation and helps a woman prevent or cope with painful sensations after 25 minutes. The effect of the medicine lasts 6 hours.
Nimesil for cystitis is used in complex treatment and reduces temperature and pain during urination, reduces inflammation. The medication alleviates the symptoms of the disease in women 30 minutes after administration and lasts for seven hours.
Nimesil for osteochondrosis is the most effective drug in the fight against pain and inflammation, which is caused by depletion and deformation of articular cartilage. The medicine is used according to a standard regimen as prescribed by a doctor. The course of treatment should not exceed two weeks.
Are pregnant women allowed to take the drug?
"Nimesil" is a drug belonging to the class of NSAIDs and inhibits the production of prostaglandins. This means that it can harm the fetus or its mother. Also, the drug may cause the ductus arteriosus to be blocked prematurely. The following pathologies sometimes develop because of it:
- hypertension in the pulmonary artery;
- renal dysfunction, as a result of which the appearance of renal failure, aggravated by oligodyramnia, cannot be excluded;
- bleeding;
- weakening of uterine contractility;
- peripheral edema.
Pregnant women should refrain from using Nimesil
So, it is clear: the drug is absolutely incompatible with a healthy pregnancy. Lactation is also a contraindication.
How does Nimesil interact with other medications?
Pharmacodynamics
If you use Nimesil with glucocorticosteroids, you can get a gastrointestinal ulcer/bleeding.
Combining it with antiplatelet drugs and SSRIs, say fluoxetine, can increase the likelihood of GI bleeding.
The effects of anticoagulants such as warfarin may be increased by taking NSAIDs. But the increased likelihood of bleeding makes this combination much less useful. For those who have serious problems with coagulation, this is even more contraindicated. If it is impossible to do without this combination, you should carefully monitor how well the blood clots.
Interaction with diuretics
"Nimesil", like any other NSAID drug, can make the effect of diuretics weaker. If the patient is not sick with anything else, nimesulide slows down the excretion of sodium for some time due to the effect of furosemide, somewhat less - the excretion of potassium, and indeed the result of using a diuretic. If the drug nimesulide and furosemide are used simultaneously, the result is a 1/5 decrease in the area under the concentration-time curve, and also a decrease in the cumulative excretion of furosemide without distorting the renal clearance of the same drug. So if kidney/heart pathologies are detected, this combination should be used with extreme caution.
You should be careful with the combination of Nimesil and diuretics
ACE inhibitors and angiotensin-2 receptor antagonists in combination with Nimesil
If you use these two types of drugs together with NSAIDs, it is possible that the effect of the former will be weaker. If there is even mild renal failure, this sometimes spoils the functioning of the kidneys and provokes their acute failure. It is already irreversible. All this must be taken into account if a person uses Nimesil with ACE inhibitors or angiotensin-2 receptor antagonists. So great caution is required from a specialist if he prescribes such a combination of medications. Especially if the patient has reached old age. The patient needs to drink a lot of water, and the functioning of his kidneys must be kept under very close control throughout the entire duration of such therapy.
How does Nimesil interact pharmacokinetically with other medications?
NSAIDs are known to impair the elimination of lithium from the human body, thereby increasing its toxicity and blood levels. When prescribing nimesulide to someone who is taking lithium drugs, the doctor is obliged to monitor how much lithium accumulates in the patient’s blood.
No significant problems have been identified caused by the combination of Nimesil with any of the following drugs:
- glibenclamide;
- digoxin;
- cimetidine;
- antacids.
“Nimesil” can be combined with some drugs without problems
When prescribing a patient to take nimesulide with a time interval between it and methotrexate of less than a day, the doctor must be careful: this can increase the level of methotrexate in the blood, and the harm from it too.
Due to their effect on renal prostaglandins, nimesulide and other inhibitors of this substance sometimes increase the nephrotoxicity of cyclosporines.
How do other medications interact with nimesulide?
According to research, the following medications displace nimesulide from binding zones:
- tolbutamide;
- salicylic acid;
- valproic acid.
Although this was found in blood plasma, nothing similar was seen in clinical use.
Buy Nimesil granules for suspension 100 mg 2 g No. 30 in pharmacies
Instructions for use Nimesulide gran. d/susp. 100mg 2g No. 30
Dosage forms granules d/susp 100 mg 2g Synonyms Aponil Nise Nemulex Nimesulide Nimesulide-Teva Nimica Nimulide Prolide Sulaydin Group Anti-inflammatory drugs of different groups International nonproprietary name Nimesulide Composition Active substance - nimesulide. Manufacturers Rompharm (Romania)
Pharmacological action Pharmacodynamics. Nimesulide is a non-steroidal anti-inflammatory drug from the sulfonamide class. It has anti-inflammatory, analgesic and antipyretic effects. Unlike non-selective NSAIDs, nimesulide mainly inhibits cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglandins at the site of inflammation; has a less pronounced inhibitory effect on cyclooxygenase-1 (COX-1). Pharmacokinetics. Nimesulide is well absorbed from the gastrointestinal tract (GIT). The maximum concentration in blood plasma after oral administration of a single dose of nimesulide, amounting to 100 mg, is achieved on average after 2 - 3 hours and is 3-4 mg / l. Area under the curve of “conhepatic” transaminases) you should stop taking the drug and consult your doctor. Despite the rarity of visual impairment in patients taking nimesulide concomitantly with other NSAIDs, treatment should be stopped immediately. If any visual disturbance occurs, the patient should be examined by an ophthalmologist. The drug can cause fluid retention in tissues, so patients with high blood pressure and cardiac problems should use Nimesil with extreme caution. In patients with renal or heart failure, Nimesil should be used with caution, as renal function may deteriorate. If the condition worsens, treatment with Nimesil should be stopped. Clinical studies and epidemiological data suggest that NSAIDs, especially at high doses and with long-term use, may lead to a small risk of myocardial infarction or stroke. There is insufficient data to exclude the risk of such events when using nimesulide. The drug contains sucrose, this should be taken into account by patients suffering from diabetes mellitus (0.15-0.18 XE per 100 mg of the drug) and those on a low-calorie diet. Nimesil is not recommended for use in patients with rare hereditary diseases of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltose deficiency. If signs of a “cold” or acute respiratory viral infection occur during treatment with Nimesil, the drug should be discontinued. Nimesil should not be used simultaneously with other NSAIDs. Nimesulide can change the properties of platelets, so caution must be exercised when using the drug in people with hemorrhagic diathesis, however, the drug does not replace the preventive effect of acetylsalicylic acid in cardiovascular diseases. Elderly patients are especially susceptible to adverse reactions to NSAIDs, including life-threatening gastrointestinal bleeding and perforation, deterioration of renal, liver and cardiac function. When taking the drug Nimesil for this category of patients, proper clinical monitoring is necessary. Like other drugs of the NSAID class that inhibit prostaglandin synthesis, nimesulide can adversely affect pregnancy and/or embryo development and can lead to premature closure of the ductus arteriosus, hypertension in the pulmonary artery system, impaired renal function, which can lead to renal failure with oligodyramnia, to an increased risk of bleeding, decreased uterine contractility, and the occurrence of peripheral edema. In this regard, nimesulide is contraindicated during pregnancy and lactation. The use of the drug Nimesil can negatively affect female fertility and is not recommended for women planning pregnancy. When planning a pregnancy, consultation with your doctor is necessary. There is evidence of the occurrence in rare cases of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other NSAIDs. At the first signs of a skin rash, damage to the mucous membranes or other signs of an allergic reaction, Nimesil should be discontinued. The effect of the drug on the ability to drive vehicles and operate machinery. The effect of the drug on the ability to drive vehicles and operate machinery has not been studied, therefore, during treatment with the drug, caution should be exercised when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Storage conditions Store out of the reach of children at a temperature not exceeding 25 C.
Similar means
The doctor may prescribe some other remedy that will act in much the same way as Nimesil. The composition in this case will also be similar to this medicine. A specialist can prescribe an analogue if the patient is allergic to one or another component of this drug. But usually in such a way that it does not cause any “side effects”. The main analogues of "Nimesil" are as follows:
- "Kokstral";
- "Nimesulide";
- "Remisid";
- "Nise";
- "Aponil";
- "Nimika";
- "Nimulid";
- "Nimegesic";
- "Nimid."
"Nimid"
Complete analogues of this product
All medications containing nimesulide are complete analogues, that is, identical products. They are available in any form. In terms of properties, indications and contraindications, these analogues are similar to Nimesil. They are made by many pharmaceutical companies. Manufacturers' technologies differ, albeit slightly. So there are many differences between drugs produced by different companies:
- chances of “side effects”;
- bioavailability;
- strength of effects.
Here are the analogues of Nimesil that are more widely known than others:
- nimesulide tablets. , Russian, “Obolenskoye”, “Izvarino-Farma”, “Berezovsky”;
- "Nimulex granulate". Manufacturer: in Romania;
- "Flolide granulate." in Italy;
- Nimesulide Teva tablets. Manufacturer: Bluepharma Industria in Portugal.
"Nimesulide Teva"
Any nimesulide tablets should be taken either during a meal or after completing it. They should be washed down with not too much water at ambient temperature. The dose and course are the same as for Nimesil.
Since the end of 2013, you can purchase another analogue of the drug “Nimesil”. This is “Affida Fort” - a full-fledged analogue, which is also produced in the form of granulate - the raw material from which the suspension is made. It is manufactured by .
Reviews for osteochondrosis
94% of people taking Nimesil and participating in the survey noted that the drug is incredibly effective if taken to suppress the discomfort caused by spinal osteochondrosis. Here are some reviews.
Alexander, 38 years old:
“Nimesil, as well as most of its analogs, helps me with pain associated with osteochondrosis. The first time I took it for two weeks, according to the doctor’s recommendations, and now I resort to it only when necessary. By the way, it also eliminates toothache well and for a long time.”
Olga, 52 years old:
“This is the only drug that helped me with terrible pain in the spine (osteochondrosis). The popular drugs Movalis and Mydocalm did not help me at all, unfortunately.”
Review of "Nimesil" for osteochondrosis
Zhanna, 31 years old:
“I have been suffering from severe back pain for many years. I have been examined more than once, used physiotherapy and therapeutic massages. I consulted a neurologist, osteopathic doctors, even chiropractors, then there were leeches, gravity couches, massage. I can’t say that it was all in vain, but the effect did not last long. After some time, the pain worsened again. Sometimes you just want to cry from hopelessness. Doctors recommend pain relief.
For quite a long time I could not find a suitable painkiller for myself. Then I came to the conclusion that of all the medications I tried, only two helped me: Nimesil and Nice. Both contain the main active ingredient nimesulide.
Nimesil is a powder that needs to be dissolved in a small amount of warm water. It begins to act after 15-20 minutes. Sometimes the pain disappears completely, sometimes not completely, I don’t even know what to connect this with. But the effect, whatever one may say, is quite good. Of course, you shouldn’t get carried away with it, as side effects may develop in the gastrointestinal tract. “I believe that it should be taken strictly on the doctor’s recommendation.”
Evgeniy, 68 years old:
“I took the drug almost every day: I poured the contents into my mouth and washed it down with water (I was never able to prove to him that the powder needed to be dissolved). The effect develops within 30 minutes. The pain under the influence of Nimesil becomes less intense, almost imperceptible, and even a certain flexibility appears. True, the pain does not completely subside even after the blockade. The only way to get rid of pain for a day or two is, oddly enough, 100 g of regular vodka. However, you won’t last long with this method of treatment either.”
For what diseases do you need to take nimesil?
The drug is used as prescribed by a doctor as a “second-line” medication and is added to therapy additionally when other drugs fail to relieve an attack of pain and relieve symptoms of inflammation that are caused by:
- toothache;
- painful menstruation and inflammation of the genital organs in women and men;
- damage to joints and ligaments that occur due to injuries, dislocations, fractures, sprains;
- pain in the spine and back;
- degenerative changes in joints with osteoarthritis.
