Multiple jaw cysts: Gorlin-Goltz syndrome

What is a cyst? Jaw cyst

A cyst is a cavity that is lined with epithelium and filled with fluid or soft material.
The formation of teeth (odontogenesis) is a complex process in which connective tissues and epithelium (enamel organ, dental follicle and dental papilla) participate.

The enamel organ refers to an epithelial structure derived from the oral ectoderm. The dental follicle and dental papilla are ectomesenchymal structures, because they are partly derived from neural crest cells.

For each tooth, odontogenesis begins with the apical (affecting the tip of the tooth root) proliferation of the epithelium of the oral mucosa, known as the dental lamina. The dental lamina gives rise to the enamel organ, a cap-shaped structure that subsequently takes on the shape of a bell. After the formation of the enamel organ, the dental lamina cord usually fragments and degenerates. However, small islands of dental lamina may remain after tooth formation. They are believed to be responsible for the development of some odontogenic cysts and tumors.

The enamel organ has four types of epithelium. The inner lining of the enamel organ is called the inner enamel epithelium and becomes the ameloblastic layer that forms tooth enamel. The second layer of cells adjacent to the inner enamel epithelium is the intermediate layer. Adjacent to this layer is the stellate reticulum, followed by the outer enamel epithelium. The enamel organ is surrounded by loose connective tissue known as the dental papilla. Contact with the epithelium of the enamel organ causes the dental papilla to produce odontoblasts, which form dentin. As odontoblasts lay down dentin, they induce ameloblasts to form enamel.

After initial crown formation, a thin layer of enamel organ epithelium, known as Hertwig's root sheath, grows at the apex of the tooth root. This epithelial expansion later becomes fragmented but leaves behind small nests of epithelial cells known as Malassez remnants in the space of the periodontal ligament. They are the source of epithelium for most periapical (radicular) cysts, but do not cause any odontogenic neoplasms, with the exception of squamous odontogenic tumor.

Why do jaw cysts form?

Odontogenic cysts (developing or inflammatory) get their name from the nature of their origin. Most jaw cysts are lined by epithelium, which is derived from odontogenic epithelium.

The occurrence of such cysts is usually associated with unerupted teeth (third molars of the lower or upper jaw, second premolars of the lower jaw, and canines of the upper jaw). They can also form near additional teeth and in combination with odontomas. The occurrence of odontogenic cysts is rarely associated with baby teeth.

Most often, jaw cysts are discovered between the ages of 10 and 30 years. Men, especially white-skinned men, suffer from them more often.

In most cases, dental cysts do not manifest themselves in any way and are an accidental finding obtained during an X-ray examination. But, in some cases, they can reach significant sizes, which lead to the expansion of bone tissue, but even they may not give pronounced symptoms until a secondary infection occurs.

How do jaw cysts appear?

In most cases, the cyst does not cause significant symptoms. Its development can be provoked by incorrect treatment of dental diseases or caries.

Odontogenic cysts are usually distinguished by type of origin:

· dentofacial cysts – their occurrence is associated with the crown of a tooth that could not erupt;

· keratocysts – are a consequence of Nevoid basal cell carcinoma syndrome;

radicular or radicular cysts – are of inflammatory origin and most often result from a reaction to necrosis of the dental pulp;

· bifurcation buccal cyst – typical for children 5-10 years old, it is formed in the area of ​​buccal bifurcation of the first molars of the lower jaw;

· primary cyst – in most cases it is a keratocystic odontogenic tumor;

· orthokeratinized cyst – also refers to a subtype of keratocystic odontogenic tumor;

· eruption cyst – usually formed from a degenerating dental follicle and forms in the gum when the tooth erupts;

· newborn gum cyst – formed from the remains of the dental plate on the gum of a newborn;

· adult gingival cyst – is a variant of the lateral periodontal cyst;

· lateral periodontal – a non-inflammatory cyst on the side of the tooth, formed from the remains of the dental plate;

· calcifying cyst is a rather rare pathology, which is characterized by cystic and neoplastic signs;

· glandular cyst is a formation with a respiratory epithelial lining and potential relapse; in its manifestations it is similar to the central variant of poorly differentiated mucoepidermoid carcinoma.

Odontogenic cysts are difficult to detect at an early stage. It gives virtually no symptoms. The patient may be alarmed by tooth displacement or a change in the color of the diseased tooth. If the cyst has reached a significant size, the patient may notice protrusion of the bone structures.

A long asymptomatic course can lead to the formation of inflammatory processes, which are dangerous due to the development of suppuration and can provoke pathological fractures of the jaw bones.

If a cyst has formed in the upper jaw, it can cause nosebleeds, headaches and impaired nasal breathing.

The main symptoms associated with the presence of an odontogenic cyst (pain, fever, inflammatory changes in the oral cavity) usually appear in the later stages of the disease.

Differential three-dimensional diagnosis of keratocysts of the jaws

M. A. Chibisova

Doctor of Medicine, Professor, Rector, Head of the Department of Radiology in Dentistry, Private Educational Institution "SPbINSTOM" (St. Petersburg), Chairman of the StAR section "Radiation diagnostics in dentistry"

A. A. Zubareva

Doctor of Medicine, Professor of the Department of Otorhinolaryngology with the clinic of PSPbSMU named after. acad. I. P. Pavlova, Professor of the Department of Radiology in Dentistry SPbINSTOM (St. Petersburg)

A. L. Dudarev

Doctor of Medical Sciences, Professor of the Department of Radiology in Dentistry SpbINSTOM (St. Petersburg)

A. V. Kholin

Doctor of Medical Sciences, Professor, Head of the Department of Radiation Diagnostics of North-Western State Medical University named after. I. I. Mechnikova (St. Petersburg)

E. V. Kaizerov

Assistant at the Department of Radiation Diagnostics of North-Western State Medical University named after. I. I. Mechnikova (St. Petersburg)

R. Kh. Charyev

postgraduate student of the Department of Maxillofacial Surgery and Surgical Dentistry of PSPbSMU named after. acad. I. P. Pavlova (St. Petersburg)

Summary

The use of modern methods of radiation diagnostics is also justified in the postoperative period for dynamic analysis of the recovery period of patients with keratocysts of the jaws. The use of modern high-tech methods of radiation diagnostics, such as digital orthopantomography (OPT, OPTG), spiral (MSCT) and cone-beam computed tomography with dynamic densitometry (CBCT, 3DCT, 3DCT), along with a detailed analysis of clinical and histological data, can significantly improve the quality assessment of the state of the dental system in normal conditions and in the detection of pathological processes. Three-dimensional tomography (MSCT and CBCT) allows for differential diagnosis between types of cystic formations, analysis of the extent of spread of the pathological process to surrounding tissues and determination of the most appropriate method of surgical intervention, including in patients with jaw kertocysts.

Keywords:

keratocyst, odontogenic cysts of the jaws, cone beam computed tomography (CBCT, 3DCT, 3DCT), multispiral X-ray computed tomography (MSCT).

Introduction

Keratocysts of the jaws, according to various authors, make up from 5.4 to 17.4% of all odontogenic cysts [2, 5, 11]. Up to 10% of patients are treated in specialized dental institutions for treatment of keratocysts of the jaws. Keratocysts are prone to recurrence, which occurs as a result of incomplete removal of the epithelial lining of the cyst. The cause of relapses is also the high activity of collagenase in the cyst wall and high fibrinolytic activity [1, 2].

Keratocyst belongs to the group of odontogenic dysembryogenetic cysts (international histological classification of odontogenic tumors, cysts and other tumor-like formations of the jaw bones WHO, Geneva, 1972), is a malformation of the maxillofacial region, is formed as a result of impaired differentiation of the epithelium of the enamel organ during ontogenesis, histologically represents It is a bone cavity lined with keratinized multilayer epithelium [2, 6, 7, 11].

Despite the rapid development of radiological diagnostic methods in recent decades, the emergence of spiral CT, as well as cone-beam dental volumetric tomography, there are no clear differential diagnostic criteria for determining the nature of cystic formation of the jaws [8, 9]. The main routine method of radiology diagnostics in dentistry is still orthopantomography and its digital improvement, which, of course, allows one to obtain a lot of useful information on the state of the dental system, including for the assessment of cystic formations [10]. However, despite the advantages of OPTG as a widespread, economically feasible and fairly informative method of radiological diagnostics in dentistry, there are a number of limitations and errors of this method that do not allow reliable interpretation of all possible radiological signs of a cystic formation [1-5].

Rice. 1. Keratocyst of the angle and ramus of the lower jaw on the left. MSCT. Rice. 2. Keratocyst of the body, angle and ramus of the mandible. Clear uneven external contour, lobular structure, pseudosepta. 3DCT. Rice. 3. Keratocyst of the body, angle and ramus of the mandible with extension to the condylar and coronoid processes. Size 63 mm. MSCT.

Histologically, there are two variants of the structure of keratocysts: parakeratotic and orthokeratotic. The parakeratotic variant is the most common, the most aggressive in terms of the rate of growth and destruction of bone tissue, as well as the frequency of relapses, and is represented by 5-7 layers of epithelium with a characteristic basal layer, the cells of which are cubic or cylindrical in shape with a vertical arrangement of hyperchromic nuclei. The cyst wall is represented by loose connective tissue with swelling of the subepithelial parts without inflammatory infiltration. In the orthokeratosis variant, the epithelium is more thickened, without a clearly defined basal layer, with a large area of ​​the superficial part in a state of true keratosis [11].

Purpose of the study

The purpose of our study was to develop differential diagnostic clinical and radiological criteria for diagnosing “keratocyst” using clinical data from a dental examination of the patient, as well as the capabilities of computed tomography methods, such as densitometry of the contents of the cystic cavity, surrounding bone tissue and soft tissues of the jaw area in the perifocal zone, the degree of destruction of the spongy bone substance of the jaws, cortical plates, metric indicators of the cystic cavity in three dimensions, the direction of cyst growth, connection with the teeth, neurovascular structures of the jaws. The data obtained can be used for the optimal choice of treatment method, the extent of surgical intervention in order to preserve the jaw bone, temporomandibular joint, teeth as much as possible, and prevent damage to the neurovascular formations of the jaws.

Rice. 4. Keratocyst contents: soft tissue component + air. Extensive defect of the vestibular cortical plate of the body of the lower jaw. MSCT. Rice. 5. Immersion of intact roots into the cyst. MSCT.

Materials and methods

The results of clinical and computed tomographic examination (digital OPTG, MSCT and dental volumetric tomography) of 46 patients with keratocysts of the jaws, confirmed by cytohistological examination data, were analyzed. The analysis was carried out using three formalized charts: clinical (complaints, anamnesis, objective examination data), 3D-CT cystogram (x-ray semiotics of keratocysts), local densitometry in various zones (using HU units for MSCT and UE for dental volumetric tomography). This group of patients was assessed according to the following clinical and radiological criteria: frequency distribution of keratocysts in different age groups, gender distribution, disease history (duration of the cyst, its growth rate, connection with carious teeth, pain), localization in various parts of the lower jaws, jaw deformation, condition of the mucous membrane, gum pockets, presence of teeth in the projection of the cyst and the condition of their roots, metric characteristics of keratocysts in three dimensions, densitometric characteristics of the contents of the cyst, capsule and surrounding bone structures and soft tissues, condition of the surrounding bone tissue, presence of defects cortical plates, impact on the mandibular canal, temporomandibular joint.

Results and discussion

Table No. 1. Distribution of keratocysts by age in men

Table No. 2. Distribution of keratocysts by age in women

Data from tables No. 1 and 2 demonstrate that keratocysts were diagnosed in men aged 11 to 74 years (25 cases) and women aged 13 to 76 years (21 cases). The highest incidence of keratocysts in men is between the ages of 30 and 60 years - 15 (60%), in women - from 20 to 40 years - 12 (57.2%).

Table No. 3.
Clinical symptoms of keratocysts

As the data in Table No. 3

, in a third of cases, 16 (34.8%), there were no complaints. The diagnosis was made by X-ray examination. Complaints of swelling and deformation of the jaw were typical - 30 (65.2%). Only 6 (13%) patients complained of pain. Characteristic signs during the dental examination were swelling of the jaw along the transitional fold - 30 (65.2%), adentia in the projection of the cyst - 23 (50%), pathological mobility of teeth in the projection of the cyst - 20 (43.5%), crepitus - 19 (41.3%) and defects of cortical plates - 9 (19.6%) upon palpation. Electroodontometry data in 42 (91.3%) cases corresponded to standard values. Not a single case of deep dental caries in the projection of the cyst has been recorded.

At the stage of radiological diagnostics using digital OPTG, spiral CT and dental volumetric tomography, the following data were obtained.

Table No. 4. Syndromic and symptomatic X-ray computed tomographic characteristics of jaw keratocysts

The data in Table No. 4 demonstrate that the typical localization of keratocysts was the body of the lower jaw at the level of premolars and molars, the angle and ramus of the lower jaw, and due to the large size of the keratocyst, it spread to two - 13 (28.3%) - or three sections of the lower jaw - 9 ( 19.6%), and in three cases reached the condylar and coronoid processes (6.5%).

Keratocysts are characterized by a lobulated structure of the cystic cavity - 26 (56.5%) with pseudosepta, which are formed by keratin masses (Fig. 1-2). A single-chamber structure was observed with small sizes of the cystic cavity (with sizes less than 10 mm in 100% of cases, with sizes of 10-30 mm in 30% of cases).

In the observations, keratocysts measuring more than 30 mm predominated - 29 (63%), keratocysts measuring 10-30 mm - 12 (26.1%). A cystic cavity less than 10 mm in size occurred in 5 cases (10.9%).

The internal contours of the cyst are clear in most cases - 39 (84.8%), uneven - 29 (63%). The external contours of the cyst were also clear in most cases - 39 (84.8%), uneven - 27 (58.7%).

In more than half of the observations, heterogeneous contents of keratocysts were revealed - 25 (54.3%). Among keratocysts with homogeneous contents, the soft tissue component predominated - 12 (26.1%) (Fig. 3

-
4).
Characteristic was swelling of the lower jaw, which was observed in 2/3 of the subjects - 30 (65.2%) with thinning - 46 (100%) and defects - 37 (80.4%) of the cortical plates ( Fig. 5

). A common sign of keratocyst of the mandible was pushback (19 (41.3%)) or partial destruction (13 (28.3%)) of the wall of the mandibular canal.

The characteristic direction of growth of keratocysts is along the long axis of the lower jaw, spreading to 3 or more teeth - 29 (63%). Immersion of the root into the cystic cavity was observed in 12 (26.1%) patients (Fig. 5). In 5 (10.9%) cases, partial lysis of the root embedded in the cyst was observed. In the keratocyst area, half of the patients—23 (50%)—had secondary adentia.

Table No. 5. Densitometric characteristics of the contents of keratocysts

Along with studying the features of 3D X-ray CT images of keratocysts, we studied quantitative densitometric parameters. In table No. 5

it is demonstrated that, according to local densitometry, the contents of keratocysts were represented by a fat-like component - 4 (8.7%), liquid - 5 (10.9%) and a soft tissue component - 12 (26.1%). In more than half of the cases, the contents were heterogeneous, with an admixture of air - 25 (54.3%).

Conclusion

Spiral computed tomography and dental volumetric tomography (CBCT), taking into account the clinical features of the development of keratocysts, provide more complete information about the cystic formation of the jaws due to the possibility of three-dimensional visualization, assessment of size and localization without errors associated with patient positioning and projection distortions, more accurate assessing the condition of cortical plates at different levels in different projections in order to accurately determine cortical defects. These methods make it possible to obtain detailed information about the relationship between the cystic cavity and such important anatomical structures as the mandibular canal and condylar process. The use of local densitometry makes it possible to quantitatively assess the contents of the cystic cavity, the condition of the capsule, surrounding bone tissue and soft tissues, signs of the presence of osteoreparative processes, as well as the condition of the roots of the teeth involved in the pathological process.

conclusions

The result of our study was the development of detailed clinical and radiological semiotics of mandibular keratocysts using radiological symptoms, densitometric data and clinical examination data.

As a result of the study, it can be concluded that keratocysts are more common at a young age, are localized mainly in the body, angle and ramus of the lower jaw at the level of the molars, do not have significant clinical manifestations, with the exception of gradually increasing deformation of the jaw, are large in size, have irregular form due to distribution along the long axis of the jaw and high osteolytic activity, are not associated with carious teeth, although they can cause lysis of tooth roots, lead to the formation of extensive defects in the cortical plates, and are prone to pushing back and lysis of the walls of the mandibular canal.

How are odontogenic cysts diagnosed?

The leading method for identifying odontogenic cysts is radiography, which is capable of visualizing jaw cysts at an early stage of their development. On an x-ray image, the cyst is distinguished by the presence of clear boundaries, and the formation itself gives a characteristic shadow of a round or oval shape, immersed in the sinus of the tooth root.

Ultrasound examination also helps to recognize odontogenic cysts.

As already mentioned, pronounced symptoms are characteristic of the late stage of development of a pathological formation, therefore it is difficult to diagnose a cyst at the initial stage, relying only on symptoms.

The final diagnosis is made on the basis of histological examination. It is important to differentiate an odontogenic cyst from other pathologies (adenomatoid odontogenic tumor, ameloblastic fibroodontoma and calcifying epithelial odontogenic tumor).

The CT scan method is widely used in the diagnosis of jaw cysts to confirm the presence of calcifications along the wall of the cyst, as well as tiny spots that are usually not found on x-rays. In addition, computed tomography is necessary during the surgical planning stage.

Multiple jaw cysts: Gorlin-Goltz syndrome

Gorlin-Goltz syndrome, also known as Nevoid Basal Cell Carcinoma Syndrome (NBCS), is a multisystem disorder first described by Gorlin and Goltz. The incidence of this disease is estimated at 1 case per 50,000-150,000 people and depends on the specific region. This rare autosomal dominant disease is characterized by disruption of several organs and systems, which affects the skeleton, eyes, skin, reproductive and nervous systems. However, all of the above symptoms are rarely observed simultaneously in one patient. The pathogenesis of the syndrome is associated with a violation of the long arm of chromosome 9 (q22.3-Q31) of the pTCH1 gene, the clinical symptoms of which do not appear in a heterogeneous ratio. The main clinical signs appear in the form of multiple odontogenic keratocysts, basal cell nevi and skeletal abnormalities. This article presents a case of a 16-year-old patient who sought treatment for multiple odontogenic keratocysts, which was subsequently diagnosed as Gorlin-Goltz syndrome. This example highlights the need and importance of a thorough clinical and radiographic examination of patients with jaw cysts.

Clinical case

A 16-year-old patient presented to the Department of Oral Medicine and Radiology, Institute of Dental Sciences, Belgaum, with the chief complaint of swelling in the left posterior region of the mandible for the last 15 days. It turned out that the swelling appeared suddenly, without accompanying attacks of pain or any discharge. The patient's medical history, family history and available dental data did not reveal any facts that could provoke or be associated with this pathology. During a general somatic examination, it was found that the patient was of average build, normally well-nourished, with a normal gait; kyphosis was also diagnosed. Extraoral examination revealed facial asymmetry, prognathism of the lower jaw, hypertelorism and strabismus of the left eye (Figure 1). During the intraoral examination, a swelling measuring 3 cm × 1 cm was discovered, occupying the vestibular area from the 34th to the 36th tooth (the 33rd tooth is missing). On palpation, the swelling has a hard consistency, is painless, expands the buccal cortical plate in the area of ​​34-36 teeth. Based on the history and clinical picture, a preliminary diagnosis of an odontogenic cyst was made, with the need for differential diagnosis with an odontogenic keratocyst. The panoramic radiograph showed four multilocular areas of radiolucency and one single-locular radiolucency with jagged edges. Areas of multilocular defects covered the body of the lower jaw, extending to the right and left to the ramus and left joint. The single-chamber area of ​​clearing was located in the area of ​​the tuberosity of the upper jaw on the left (photo 3). Fine needle aspiration biopsy of the swelling area was performed using a 24-gauge needle. The aspirated composition was creamy white in color with a protein concentration of 3.3 g/100 ml. Considering the possibility of Gorlin-Goltz syndrome, the patient also underwent chest radiography, computed tomography (CT), and lateral cephalography. A chest x-ray revealed cleft ribs 2, 3 and 4 on the right, and a similar pattern on the 3rd and 4th ribs on the left (Figure 4). A CT scan diagnosed a bilateral expanding lytic lesion of the mandible (photo 5), and a lateral cephalogram revealed overlap of the sella turcica (photo 6).

Photo 1. Extraoral examination revealed asymmetry, hypertelorism and strabismus.

Photo 2. Intraoral swelling in the buccal vestibule of the oral cavity.

Photo 3. The orthopantomogram revealed several multilocular radiolucencies with jagged edges.

Figure 4: Split ribs on chest x-ray.

Figure 5: Computed tomography revealed a bilateral expanding lytic lesion of the mandible.

Photo 6. On the lateral cephalogram, the overlap of the sella turcica is visualized.

After an incisive biopsy, histopathological examination of the sample revealed a cystic epithelium consisting of darkly stained basal cells arranged in a palisading pattern. The superficial layer revealed parakeratosis and a corrugated appearance, which could confirm the diagnosis of keratocyst (Figure 7).

Photo 7. Hyperchromatic palisade-like basal layer and corrugated parakeratotic surface (hematoxylin-eosin, × 10).

Discussion

Gorlin-Goltz syndrome occurs with equal frequency in both men and women of almost all ethnic groups. The disease is diagnosed in young patients, in most cases in people aged 17 to 35 years. This pathological condition is very difficult to diagnose in early childhood, since its symptoms appear gradually during growth, but a good prognosis for treatment is characteristic primarily for cases diagnosed in the early stages. The main and secondary symptoms of this pathology, summarized by Evans and colleagues in 1993, will help diagnose Gorlin-Goltz syndrome.

Main criteria:

• more than two basal cell carcinomas or one in patients younger than 20 years of age;
• odontogenic keratocysts of the jaws;
• three or more palmar or plantar recesses;
• bilayered areas of calcification of the falx cerebellum and cerebellum;
• splitting, fusion, or noticeable protrusion of ribs;
• direct relatives with inherent Gorlin-Goltz syndrome.

Secondary criteria:

• macrocephaly;
• congenital anomalies (cleft lip or palate, prominent frontal ridges, large face, moderate to severe hypertelorism);
• other skeletal anomalies (Sprengel deformities, extensive chest deformities, syndactyly of the fingers);
• X-ray abnormalities such as sella occlusion, spinal abnormalities, defects of the arms and legs, or fire-like lesions on the arms and legs;
• ovarian fibroma or myeloblastoma.

Two main criteria or one main and two minor ones are sufficient to make a diagnosis of Gorlin-Goltz syndrome. In our case, the diagnosis was confirmed by the presence of two main criteria (odontogenic keratoxitis of the jaws and cleft ribs) and two minor ones (congenital anomalies: prominent frontal tuberosities and hypertelorism; radiological abnormalities: kyphosis and sella turcica overlap).

Odontogenic keratocysts may be the first symptom of the syndrome. They are usually discovered incidentally on an x-ray. Cysts may appear clinically when infected as swelling. In our case, the diagnosed cysts were the first symptom of the later verified syndrome. Odontogenic keratocysts in Gorlin-Goltz syndrome usually present in the form of single-chamber or multi-chamber areas of radiolucency of the body, angle or ramus.

Various conservative approaches to the treatment of large cysts in young patients have been proposed, aimed at preserving soft and hard tissues, including teeth. These include techniques such as marsupialization, decompression, enucleation with Carnoy's solution, peripheral osteoectomy with or without Carnoy's solution, jaw resection, or surgical removal of the keratocyst followed by cryotherapy with Carnoy's solution. Genetic consultation is mandatory for all patients, since 50% of patients can transmit the disease to a child. Prenatal diagnosis during pregnancy can be carried out in cases of identified mutations in a family with a history of the syndrome.

In our case, the patient was referred to the Department of Oral and Maxillofacial Surgery, where he underwent enucleation and curettage of the cystic lesions (Figure 8). The patient was informed about the features of the syndrome with recommendations to avoid prolonged exposure to sunlight. Six months later, an x-ray revealed good progress in the healing of the cystic cavities with the formation of bone tissue. The patient is still under observation (Figure 9).

Photo 8. View after surgical enucleation of the cyst.

Photo 9. Visualization of the bone healing process 6 months after surgery.

conclusions

Patients with Gorlin-Goltz syndrome require a special multidisciplinary medical and dental approach during treatment. Early diagnosis ensures the prevention of complications and the selection of the correct treatment algorithm. Young patients without a history of basal cell carcinoma can simply take precautions and avoid radiation exposure. Diagnosed and treated patients should be closely monitored, as the recurrence rate of the syndrome reaches 63%.

Authors: S. Manjima, Zameera Naik, Vaishali Keluskar, Anjana Bagewadi

What is the prognosis for the disease?

How successfully the situation in a patient with an odontogenic cyst will be resolved depends on at what stage the cyst was discovered, how severe the symptoms were and how it was treated.

As a rule, the use of surgical treatment gives a positive prognosis. Therapeutic treatment provides a positive prognosis only if it is started at the initial stage of the disease.

A negative prognosis may be associated with detection of the disease at a late stage: odontogenic cysts can provoke the development of serious pathologies that cause deformation of the maxillofacial tissues.

What treatment methods for jaw cysts exist?

The choice of treatment method for an odontogenic cyst directly depends on the symptoms it causes, as well as the results obtained during instrumental and laboratory diagnostics.

If surgical treatment is chosen (cystotomy or cystectomy), the maxillofacial surgeon performs complete removal of the cyst. In some cases, it is necessary to remove the cyst along with the affected parts of the tooth root. Treatment is carried out in a hospital setting.

If the choice falls on therapeutic treatment, the doctor will carry out procedures aimed at reducing inflammation. This is a long process, taking at least six months.

The first step is to drain the contents of the cyst using a special drainage tube, which is inserted into a small incision in the tumor. As the contents drain out and the tumor shrinks, the size of the tube is adjusted downward.

After removing the contents of the cyst, the dentist cleans the root canals and administers medications that destroy the tumor tissue. At the end of all procedures, the doctor uses a special solution aimed at accelerating healing.

Treatment is monitored radiographically.

Both after surgical and therapeutic treatment, the patient requires preventive measures that will help avoid the re-formation of an odontogenic cyst.

How is a dental cyst treated using cystotomy?

As noted earlier, before choosing a treatment method, the dental surgeon sends the patient for an x-ray. If, after studying the image, the surgeon chooses the cystotomy method, then local anesthesia is first performed. The anesthetic does not act immediately, so the dentist waits for some time (usually 5-10 minutes) and proceeds directly to surgical procedures.

If surgery is performed on the lower jaw with a very thin base, the jaw is preliminarily splinted to prevent a postoperative fracture.

The first thing that is done is an incision of the mucous membrane along with the periosteum. The incision is made with a surgical scalpel and has the shape of an arc. After the incision, the detachment of the mucoperiosteal flap begins. Detachment of the flap is done bluntly, using a special tool - a rasp. After detachment, the anterior wall of the jawbone opens, under which a cystic formation is located. There are clinical cases when, after detachment of the flap, the bone wall is either completely absent or thinned to such an extent that the pathological focus can be felt through it. This is due to the enormous size of the odontogenic cyst, which puts chronic stress on the bone, leading to its deformation.

If the bone wall is still preserved, it must be opened. This is done using a dental handpiece and a ball-shaped bur or cutter. The bone opens to the diameter that corresponds to the cystic formation. After opening, the anterior shell of the cyst opens, and it is this that is removed during cystotomy, all other shells are preserved. The tops of the dental roots that are in the cyst must be removed, i.e. Root resection and retrograde filling are performed.

After all the manipulations, the defect formed in the bone is covered with a mucoperiosteal flap and filled with gauze turunda soaked in Iodoform solution.